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Who is suitable for the 9-valent human papillomavirus (HPV) vaccine?

Nov 15, 2025 Source: Cainiu Health
Dr. Zhang Lu
Introduction
The 9-valent human papillomavirus (HPV) vaccine is suitable for females and males aged 9 to 45 who are not allergic to any vaccine components and have no contraindications for vaccination. Individuals with fever, acute illness, or a history of severe chronic diseases prior to vaccination should seek medical evaluation to determine whether vaccination is appropriate. Immune responses in adolescents aged 9 to 15 tend to be more robust.

The 9-valent human papillomavirus (HPV) vaccine is suitable for females and males aged 9 to 45. Individuals who are not allergic to the vaccine components and have no contraindications can receive the vaccination. If fever, acute illness, or a severe chronic medical history is present before vaccination, it is recommended to seek timely medical evaluation to determine suitability for vaccination.

In terms of age, adolescents aged 9 to 15 typically have more active immune responses, leading to higher efficiency in antibody production and longer-lasting protection after vaccination. Vaccination before exposure to HPV offers maximum preventive benefits, making this group the top priority for immunization.

Sexually active individuals under 45 years old who have not been infected with the HPV types covered by the vaccine can still gain effective protection after vaccination, reducing the risk of diseases such as cervical cancer and genital warts caused by these HPV types. Professional medical consultation is recommended prior to vaccination.

After vaccination, individuals should remain under observation at the vaccination site for an adequate period, keep the injection site clean and dry, and avoid scratching. A light diet is recommended, avoiding spicy or irritating foods. Moderate rest is advised, along with avoidance of strenuous physical activity, to support the body's stable production of antibodies.

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What dietary precautions should be taken before and after receiving the 9-valent HPV vaccine?
Before and after receiving the 9-valent HPV vaccine, it is important to maintain a light diet, avoid spicy and irritating foods, reduce alcohol consumption, ensure adequate intake of high-quality nutrients, and avoid allergenic foods. Proper nutrition can help minimize physical discomfort and support the effectiveness of the vaccine. If severe rash, vomiting, or fever exceeding 38.5°C occurs after vaccination, prompt medical attention is recommended.
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What type of HPV vaccine should a 34-year-old woman receive?
The age range for 2-valent and 4-valent HPV vaccines covers women up to 34 years old, with both requiring a vaccination schedule of one dose at months 0, 2, and 6. These vaccines can prevent high-risk HPV types 16 and 18, while the 4-valent vaccine additionally protects against types 6 and 11. They meet the basic needs for cervical cancer prevention, with relatively sufficient vaccine supply and low vaccination barriers.
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Can I get a nucleic acid test after receiving the HPV vaccine?
In general, whether nucleic acid testing can be performed after receiving the HPV vaccine depends on the purpose of the test. After getting the HPV vaccine, if nucleic acid testing is needed, you should inform healthcare providers about the type and timing of the vaccine received. For COVID-19 nucleic acid testing, there is no need to adjust the testing schedule due to HPV vaccination. However, for HPV virus testing, it is essential to consult a doctor to determine the appropriate timing for testing.
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Which dose of the 9-valent HPV vaccine is more likely to cause fever?
The second or third dose is more likely to cause fever, primarily because the body has already developed an initial immune memory to the vaccine components after the first dose. Upon subsequent vaccinations, the immune system responds more vigorously, resulting in a stronger immune response that may be accompanied by mild inflammatory reactions, thus triggering fever. Such fevers are usually low-grade, short-lived, and typically resolve on their own within 1–2 days.
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Does it matter if I'm not a virgin when getting the 9-valent HPV vaccine?
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Can the second HPV vaccine dose be administered a few days early?
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How many doses of the quadrivalent HPV vaccine are required?
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