What causes feelings of extreme fatigue, not wanting to talk, and irritability?

Nov 15, 2025 Source: Cainiu Health

Dr. Yang Ziqi

Introduction

In general, feelings of fatigue, unwillingness to talk, and irritability may be caused by insufficient sleep, excessive mental stress, neurasthenia, hyperthyroidism, depression, or other reasons. If discomfort symptoms occur, it is recommended to seek timely medical evaluation and treatment at a正规 hospital. In daily life, maintain a regular sleep schedule, eat a balanced diet rich in fruits and vegetables to supplement vitamins, and engage in moderate exercise to improve physical health.

Generally, feeling very tired, not wanting to talk, and irritability may be caused by lack of sleep, excessive mental stress, neurasthenia, hyperthyroidism, depression, or other reasons. If discomfort symptoms occur, it is recommended to seek timely medical evaluation and treatment at a正规 hospital. Specific analysis is as follows:

1. Sleep Deprivation

Chronic late-night habits or poor sleep quality lead to persistent fatigue of the brain's nerves and reduced dopamine secretion, resulting in physical weakness and irritability. It is advisable to go to bed before 11 p.m. every day, ensuring 7–8 hours of sleep. Avoid using mobile phones before bedtime; soaking feet in warm water may help improve sleep.

2. Excessive Mental Stress

Remaining under prolonged high pressure causes continuous sympathetic nervous system excitement and excessive psychological burden, leading to physical and mental exhaustion and low mood. Set aside 30 minutes daily for exercises such as jogging or yoga, talk about your stress with family or friends, and avoid accumulating negative emotions.

3. Neurasthenia

Prolonged mental tension leads to heightened nerve excitability and easy fatigue, along with cortical dysfunction, causing symptoms such as fatigue, irritability, and reduced speech. Under medical guidance, medications such as Oryzanol tablets, Vitamin B1 tablets, or Anshen Bunao Liquid may be taken. Avoid staying in noisy environments for long periods.

4. Hyperthyroidism

Excessive secretion of thyroid hormones accelerates metabolism and overstimulates the sympathetic nervous system, causing palpitations, fatigue, irritability, and reluctance to speak. Under medical supervision, medications such as Methimazole tablets, Propylthiouracil tablets, or Propranolol tablets can be used, and intake of iodine-rich foods should be reduced.

5. Depression

Insufficient secretion of 5-hydroxytryptamine (serotonin) in the brain impairs emotional regulation, leading to persistent fatigue, loss of interest, irritability, and reduced speech. Under medical guidance, medications such as Sertraline Hydrochloride tablets, Escitalopram Oxalate tablets, or Mirtazapine tablets may be prescribed, along with psychotherapy.

In daily life, maintain a regular作息 schedule; eat a balanced diet rich in fruits and vegetables to supplement vitamins; engage in moderate exercise to strengthen the body; learn to relieve stress and maintain a positive mindset; and undergo regular health check-ups to detect abnormalities early.

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