Why do I always sweat during sleep after taking antidepressants?

Nov 15, 2025 Source: Cainiu Health
Dr. Yang Ziqi
Introduction
Excessive sweating during sleep after taking antidepressants may be caused by medication side effects, overly warm environment, hyperthyroidism, diabetes, menopausal syndrome, or other reasons. If discomfort occurs, it is recommended to seek timely medical evaluation at a正规 hospital. In daily life, maintain regular sleep patterns and avoid staying up late; keep the bedroom well-ventilated and wear breathable clothing; undergo regular health check-ups to monitor bodily indicators; and follow a light diet.

Excessive sweating during sleep after taking antidepressants may be caused by medication side effects, overheating of the environment, hyperthyroidism, diabetes, menopausal syndrome, or other reasons. If discomfort occurs, it is recommended to seek timely medical evaluation at a正规 hospital. Specific causes are analyzed as follows:

1. Medication side effects: Some antidepressants affect neurotransmitter secretion, stimulating increased sweat gland activity. Consult your doctor about adjusting the dosage, wear breathable clothing before bedtime, and wipe off sweat promptly.

2. Overheating environment: High bedroom temperature or excessive bedding can impair the body's heat dissipation. Adjust room temperature to 22–25°C, choose lightweight and breathable bedding, and reduce physical activity before sleep.

3. Hyperthyroidism: Excess thyroid hormone accelerates metabolism, leading to excessive sweating. Follow your doctor’s instructions for medications such as methimazole tablets, propylthiouracil tablets, or carbimazole tablets, and regularly monitor thyroid function.

4. Diabetes: Blood glucose fluctuations or hypoglycemia can stimulate sympathetic nervous system activity, causing sweating. Monitor blood glucose regularly and take prescribed medications such as metformin hydrochloride tablets, glimepiride tablets, or insulin injection solution.

5. Menopausal syndrome: Declining estrogen levels disrupt autonomic nerve regulation, resulting in hot flashes and excessive sweating. Use estradiol valerate tablets, nylestriol tablets, or conjugated estrogens tablets as directed by your doctor, and maintain emotional stability.

In daily life, maintain regular作息 and avoid staying up late; keep the bedroom well-ventilated and wear breathable clothing; undergo regular health check-ups to monitor vital indicators; follow a light diet and reduce intake of spicy or stimulating foods.