Which is better for treating ADHD: atomoxetine or methylphenidate?

There is no absolute superiority between atomoxetine and methylphenidate in treating ADHD. Atomoxetine is suitable for patients who require long-lasting, stable symptom control or have comorbid anxiety and depression, while methylphenidate acts quickly and is better for those with明显 symptom fluctuations. The choice should be based on individual patient circumstances. If symptoms do not improve or severe adverse reactions occur after medication, it is recommended to seek medical advice promptly to adjust the treatment plan.

Atomoxetine is a selective norepinephrine reuptake inhibitor. It has a slower onset of action, requiring 1–2 weeks to achieve stable therapeutic effects, with sustained activity over 24 hours. It provides steady control of inattention, hyperactivity, and impulsivity, and has additional beneficial effects on coexisting anxiety and depressive symptoms. Its side effects are relatively mild.

Methylphenidate is a central nervous system stimulant. It works rapidly, with effects beginning 1–2 hours after administration, lasting 4–12 hours. It is particularly effective in controlling hyperactivity and impulsivity, making it suitable for patients needing rapid symptom relief or those whose symptoms are especially prominent during school hours. However, it may cause short-term side effects such as decreased appetite and insomnia.

During treatment, medications should be taken regularly as prescribed; dosage adjustments or discontinuation must not be made without medical guidance. Monitor the child's mood, appetite, and sleep patterns, and communicate any changes to the doctor for timely adjustment of the treatment plan. Combining behavioral interventions and family education can further enhance treatment outcomes.