What are the side effects of long-term use of trazodone hydrochloride tablets?

Long-term use of trazodone hydrochloride tablets may generally lead to side effects such as drowsiness and fatigue, dry mouth and constipation, dizziness and headaches, weight changes, and sexual dysfunction. A detailed analysis is as follows:

1. Drowsiness and fatigue: After prolonged use, some individuals may experience persistent drowsiness, feeling tired and lacking energy during the day, which can affect daily work and study efficiency. In severe cases, it may cause difficulty concentrating or physical exhaustion even during simple activities.

2. Dry mouth and constipation: The medication may affect saliva secretion and intestinal motility, leading to chronic dry mouth requiring frequent drinking to relieve discomfort. Slowed intestinal movement can also result in constipation, reduced bowel movements, and dry, hard stools. Some individuals may need additional assistance to defecate normally.

3. Dizziness and headaches: Most people may repeatedly experience dizziness during long-term use, especially when standing up or changing body positions. This may be accompanied by mild headaches of varying intensity. Some individuals may feel a dull ache or pressure-like pain, which typically lasts briefly but tends to recur frequently.

4. Weight changes: Some users may experience weight gain after prolonged use, possibly due to the drug's effect on appetite or metabolism. A minority may experience weight loss, often caused by mild gastrointestinal irritation from the medication leading to decreased appetite and reduced food intake.

5. Sexual dysfunction: Long-term use may affect sexual function. Men may experience erectile dysfunction or delayed ejaculation, while women may develop reduced libido. These side effects can interfere with normal life and are usually more noticeable during continued use.

If trazodone hydrochloride tablets are taken long-term, regular monitoring of bodily responses is necessary. If any of the above side effects occur and significantly impact daily life, medical attention should be sought promptly. A doctor should evaluate whether adjustments to the treatment plan are needed. Do not discontinue or alter the dosage without medical guidance.