What medication should be combined with escitalopram oxalate tablets for better treatment of depression?

When treating depression with escitalopram oxalate tablets, combination therapy may include mirtazapine tablets, agomelatine tablets, quetiapine fumarate extended-release tablets, buspirone hydrochloride tablets, or venlafaxine hydrochloride extended-release capsules. The choice of combination should be based on the severity of symptoms and individual tolerance to achieve complementary therapeutic effects. If depressive symptoms continue to worsen or suicidal thoughts occur, immediate medical attention is recommended.

1. Mirtazapine tablets: Mirtazapine improves insomnia and reduced appetite commonly associated with depression. When used in combination with escitalopram oxalate tablets, it can accelerate improvement in mood, making it particularly suitable for patients with prominent sleep disturbances or significant weight loss.

2. Agomelatine tablets: Agomelatine has both antidepressant effects and the ability to regulate sleep rhythms. Combined with escitalopram oxalate tablets, it enhances emotional control while correcting circadian rhythm disorders, thereby improving the patient's overall condition.

3. Quetiapine fumarate extended-release tablets: These help stabilize mood and reduce anxiety. They are suitable for patients with depression accompanied by psychotic features or significant anxiety. Combination use broadens the therapeutic coverage and reduces symptom fluctuations.

4. Buspirone hydrochloride tablets: This medication specifically targets anxiety relief. When combined with escitalopram oxalate tablets, it effectively alleviates symptoms such as tension, worry, and restlessness associated with depression, enhancing patient comfort.

5. Venlafaxine hydrochloride extended-release capsules: Acting on multiple neurotransmitter pathways, this medication—when combined with escitalopram oxalate tablets—is appropriate for patients with moderate to severe depression who show inadequate response to monotherapy. Dosage must be carefully controlled.

During treatment, maintain a consistent medication schedule; do not adjust the dose or discontinue use without medical guidance. Avoid spicy, stimulating foods and alcohol. Maintain regular sleep patterns, engage in mild physical activity appropriately, and closely monitor emotional and physical changes.