Can I drink licorice oral solution while taking antidepressants?

Generally speaking, whether it is safe to take licorice oral solution while taking antidepressant medication depends on specific circumstances. The detailed analysis is as follows:

If the antidepressant being taken has no known interaction with licorice and the licorice oral solution is used only short-term and in small doses to relieve mild coughing, combined use may be acceptable under a doctor's guidance. Before using, inform your doctor about the specific type of antidepressant you are taking, and take the two medications at least 1–2 hours apart to minimize potential interference with absorption.

However, if you are taking monoamine oxidase inhibitor (MAOI) antidepressants or require long-term, high-dose use of licorice oral solution, concurrent use should be avoided. MAOIs combined with licorice may increase the risk of abnormal blood pressure, while prolonged or excessive use of licorice can easily cause sodium and water retention, increasing the body's burden and potentially reducing the effectiveness of antidepressants. In such cases, it is recommended to prioritize cough remedies that do not interact with antidepressants.

During treatment, drink plenty of warm water to keep the respiratory tract moist, maintain a light diet, and avoid spicy or irritating foods that may trigger coughing. Keep a regular sleep schedule and avoid staying up late. Monitor your physical condition closely; if symptoms such as dizziness or swelling occur, discontinue the medication immediately and consult a healthcare professional.