Can mental stress cause a decrease in immunity?

Nov 20, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
In general, whether psychological stress leads to decreased immunity depends on the intensity and duration of the stress. Short-term, mild stress usually has little impact, whereas long-term or severe psychological stress may lead to reduced immune function. In daily life, it is important to learn how to regulate emotions and relieve stress through activities such as exercise, listening to music, and communicating with others.

In general, whether psychological stress can lead to decreased immunity depends on the intensity and duration of the stress. Short-term, mild stress usually has little impact, whereas long-term or severe psychological stress may result in reduced immune function. The detailed analysis is as follows:

During short-term, mild psychological stress, the body initiates a stress response, mobilizing energy to cope with pressure. At this time, immune system function may temporarily fluctuate but does not significantly decline. For example, brief anxiety before an exam typically resolves quickly afterward, allowing the body to rapidly restore balance. This kind of stress does not impair immune defenses and may even enhance the body's defensive potential to some extent.

When psychological stress persists over a long period or becomes severe, stress hormones such as cortisol remain elevated. These hormones suppress the activity of immune cells and reduce the production of immunoglobulins, weakening the body’s ability to resist pathogens. As a result, individuals become more susceptible to bacterial and viral infections, experiencing conditions like colds or other infections more frequently, and recovery tends to be slower.

In daily life, it is important to learn how to regulate emotions and relieve stress through activities such as exercise, listening to music, and communicating with others. Maintaining regular sleep patterns and a balanced diet provides strong support for the immune system, helping to prevent prolonged psychological stress and ensuring stable immune function.