Which antidepressant can help improve appetite?

Nov 21, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
Some antidepressants have minimal impact on appetite and may even improve eating, such as mirtazapine tablets, trazodone tablets, fluvoxamine tablets, sertraline tablets, and paroxetine enteric-coated sustained-release tablets. The specific choice should be based on individual constitution and medical condition. If depression is accompanied by severe loss of appetite, weight loss, or persistent low mood, prompt medical attention is recommended.

Some antidepressants have minimal effects on appetite and may even improve eating behavior, such as mirtazapine tablets, trazodone tablets, fluvoxamine tablets, sertraline tablets, and paroxetine enteric-coated sustained-release tablets. The specific choice should be based on individual physical conditions and clinical presentation. If depression is accompanied by severe loss of appetite, weight loss, or persistent low mood, prompt medical attention is recommended.

1. Mirtazapine tablets: Belonging to noradrenergic and specific serotonergic antidepressants, this medication may increase appetite in some patients. It is suitable for individuals with depression accompanied by reduced appetite and can also help improve sleep.

2. Trazodone tablets: A serotonin receptor antagonist and reuptake inhibitor, it causes minimal gastrointestinal irritation and rarely leads to decreased appetite. Some patients experience gradual recovery of eating desire after use, making it appropriate for depressed patients with concurrent gastrointestinal discomfort.

3. Fluvoxamine tablets: A selective serotonin reuptake inhibitor (SSRI), it has a relatively weaker suppressive effect on appetite compared to other drugs in the same class. Most patients can maintain normal eating patterns, making it suitable for those with mild to moderate depression who need to sustain regular dietary intake.

4. Sertraline tablets: Another SSRI with relatively mild side effects and minimal impact on appetite. A small number of patients may experience slight increases in appetite, making it ideal for individuals with depression and mild eating difficulties.

5. Paroxetine enteric-coated sustained-release tablets: The sustained-release formulation reduces gastrointestinal irritation and has less impact on appetite than conventional formulations. Most patients do not develop significant eating disturbances after taking this medication, making it suitable for patients with depression combined with anxiety who are concerned about appetite changes.

During treatment, maintain regular and light meals, avoiding spicy and greasy foods; include fresh vegetables, fruits, and high-quality protein in the diet. Create a relaxed eating environment and avoid excessive focus on food intake. Engage in moderate, gentle physical activity to help improve metabolism and appetite, thereby supporting the effectiveness of medication.