Which is more effective, dapoxetine or clomipramine?

Generally, the effectiveness of dapoxetine and clomipramine varies from person to person, so it is not possible to directly determine which one is superior. If medication is needed, it is recommended to consult a healthcare professional in advance. The detailed analysis is as follows:

Dapoxetine is a selective serotonin reuptake inhibitor (SSRI) that works by modulating neurotransmitters to prolong the ejaculatory latency period. It is suitable for both primary and secondary premature ejaculation. It acts quickly, with effects typically seen after a single dose. Common side effects include headache and nausea, but most patients tolerate it well, making it appropriate for individuals needing rapid symptom improvement.

Clomipramine belongs to the tricyclic antidepressant class and improves premature ejaculation by inhibiting norepinephrine reuptake. It also has antidepressant and anti-anxiety effects. This medication requires continuous use for several weeks before noticeable benefits occur, making it more suitable for patients with premature ejaculation accompanied by mood disorders. However, it may cause adverse reactions such as dry mouth, constipation, and orthostatic hypotension, so caution is advised, especially in elderly patients.

Due to differences in mechanisms of action and indications, the choice between these two medications should be based on the individual's specific condition, treatment goals, and overall health status. Regular follow-up visits are necessary during treatment to evaluate efficacy, and dosages should be adjusted strictly according to medical guidance. Patients should avoid self-adjusting doses or abruptly discontinuing the medication.