Can patients with depression use pethidine hydrochloride for pain relief?

Generally, patients with depression are not recommended to use pethidine hydrochloride for pain relief. In special cases of pain, its use should only follow strict evaluation and medical guidance. If any abnormalities occur, prompt medical attention is advised. Detailed analysis is as follows:

Pethidine hydrochloride is a potent analgesic that inhibits the transmission of pain signals by activating opioid receptors, but it may exacerbate depressive symptoms. Patients with depression already suffer from low mood and reduced interest; this drug may further deteriorate emotional state by suppressing dopamine secretion, potentially even inducing suicidal tendencies.

If a patient with depression requires pethidine hydrochloride due to severe trauma, postoperative pain, or advanced cancer-related pain, a physician must comprehensively evaluate the severity of pain, the patient's depressive condition, and the risk of drug interactions before formulating a treatment plan. Close monitoring of emotional changes and respiratory function is necessary during treatment. Concomitant use with other central nervous system depressants should be avoided to prevent serious adverse reactions such as respiratory depression.

Depression patients using pethidine hydrochloride must strictly adhere to medical instructions. Do not adjust the dose or discontinue the medication without authorization. Family members should provide enhanced supervision during treatment and contact the doctor immediately if any abnormalities are observed.