Does increased appetite after taking quetiapine require a dose reduction?

Whether to reduce the dose of quetiapine due to excessive eating has no absolute answer. The key principle is never to adjust the dosage independently; a doctor must make decisions based on individual circumstances. Excessive appetite may be a side effect of the medication, but any dosage adjustment must also consider the control of psychiatric symptoms and requires professional evaluation.

Quetiapine may affect the appetite regulation center in the brain, leading to increased food intake and cravings for high-calorie foods. Over time, this could result in weight gain, blood sugar fluctuations, and other health issues. However, as an antipsychotic medication, quetiapine's effectiveness is directly related to its dosage. Adjusting the dose without medical supervision can disrupt the drug's steady concentration in the body, potentially causing a relapse or worsening of underlying psychiatric symptoms—such as mood instability and disorganized thinking—risks that far outweigh those associated with overeating alone.

When significant overeating occurs, doctors will comprehensively assess the severity of the symptom, current dosage, disease progression, and the level of psychiatric symptom control. If overeating poses a health risk, the doctor might consider adjusting the dose, switching medications, or adding dietary counseling. If symptoms are mild, lifestyle interventions may be recommended instead of immediate dose reduction.

In daily life, patients should keep a record of their eating habits, actively avoid high-sugar and high-fat foods, and regularly engage in gentle physical activities such as walking or yoga. It is also essential to attend follow-up appointments as prescribed, provide detailed feedback about eating behaviors, and work closely with the doctor to develop a personalized treatment plan.