Can betahistine be taken together with mirtazapine tablets?

After evaluation by a physician, betahistine and mirtazapine tablets may be taken concurrently. There is no direct pharmacological conflict between the two medications, and their combined use can target different conditions effectively. However, self-administered combination without medical guidance is strictly prohibited. If symptoms such as worsened dizziness, significant drowsiness, or gastrointestinal discomfort occur after combining the drugs, prompt medical attention is advised.

Betahistine is primarily used to improve inner ear circulation and relieve vertigo, acting on the peripheral vascular system; mirtazapine is an antidepressant that functions by regulating central nervous system neurotransmitters. The two drugs have different mechanisms of action and exhibit no direct antagonism or synergistic toxicity.

However, mirtazapine may cause adverse effects such as dizziness and drowsiness, and betahistine may also lead to mild dizziness. When used together, the risk of adverse reactions may increase, particularly in individuals with heightened sensitivity. Dosage adjustments should be made by a physician based on the patient's clinical condition.

Medications must be taken exactly as prescribed. Maintain a consistent medication schedule to avoid missed doses, follow a light diet avoiding spicy or irritating foods, abstain from alcohol, maintain regular sleep patterns, and closely monitor physical responses and mental status to ensure safe medication use.