Can levomepromazine and fluoxetine be taken together?

It is not recommended to take levomepromazine and fluoxetine together without medical supervision, as their combined use carries risks. Whether these two medications can be used together should be determined by a qualified physician after a comprehensive assessment of the patient's condition. Detailed analysis is as follows:

Levomepromazine is an antipsychotic medication that stabilizes mental state by modulating central dopamine and serotonin receptors. Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) that improves depressive symptoms by increasing central serotonin levels. Since both drugs act on the central serotonin system, combining them may lead to excessive serotonin activity, increasing the risk of adverse effects such as dizziness, tremors, and nausea, and in severe cases, may cause emotional disturbances.

Both medications are metabolized by the liver and kidneys. Taking them concurrently increases the metabolic burden on these organs, posing higher risks for individuals with impaired liver or kidney function. Levomepromazine may cause drowsiness and dry mouth, while fluoxetine may lead to insomnia and anxiety. When used together, these side effects may interact or accumulate, negatively affecting quality of life.

In clinical practice, if combination therapy is necessary due to the patient's condition, physicians will carefully adjust dosages and closely monitor the patient's response. During treatment, patients must strictly follow medical instructions, document any physical changes, attend regular follow-up appointments, and must not alter their medication regimen without consulting their doctor.