Can I take trazodone hydrochloride tablets during the day instead of at night if it causes insomnia after taking it in the evening?

Nov 21, 2025 Source: Cainiu Health
Dr. Zhang Baohua
Introduction
If insomnia is caused by excessive medication dosage or high individual sensitivity to the drug, and the patient's mental state during the day is acceptable without significant drowsiness, consider adjusting the medication time to morning or noon, and observe whether sleep improves. In some patients, after such adjustment, the drug is metabolized during the day and its effect weakens at night, which may alleviate insomnia symptoms.

Generally, if insomnia occurs after taking trazodone hydrochloride tablets at night, whether to switch to daytime administration should be determined based on individual response. If any abnormalities occur, it is recommended to seek medical advice promptly. The detailed analysis is as follows:

If the insomnia is caused by a high drug dose or high individual sensitivity to the medication, and the patient feels alert during the day without significant drowsiness, it may be considered to adjust the dosing time to morning or noon, and monitor for improvements in sleep. In some patients, after such adjustment, the drug is metabolized during the day and its effect weakens at night, which may help alleviate insomnia.

However, if the patient already experiences daytime drowsiness or fatigue, or develops adverse reactions such as dizziness or difficulty concentrating after changing the dosing time, daytime administration is not recommended. Moreover, if the insomnia is unrelated to the medication and instead triggered by factors such as increased anxiety or environmental disturbances, simply changing the dosing time may not resolve the issue, and further evaluation of the underlying cause is needed.

Before adjusting the dosing schedule, consult with a doctor to identify the cause of insomnia and assess the feasibility of the change. Never alter the dosage or timing of medication on your own, as this may compromise treatment efficacy or worsen side effects.