Will taking agomelatine tablets make you feel happy?

Nov 21, 2025 Source: Cainiu Health

Dr. Zhang Baohua

Introduction

Agomelatine tablets are a novel antidepressant that improves mood by modulating melatonin receptors and neurotransmitters (such as dopamine and norepinephrine). In patients meeting the diagnostic criteria for depression, with standardized medication use, symptoms such as low mood and reduced interest may gradually improve over the course of treatment, and some individuals may consequently experience emotional relief or even euphoria.

Generally, taking agomelatine tablets may gradually improve depressive mood, but individual responses vary. If any abnormalities occur, it is recommended to seek medical attention promptly. Detailed analysis is as follows:

Agomelatine tablets are a novel antidepressant that improves mood by modulating melatonin receptors and neurotransmitters (such as dopamine and norepinephrine). For patients meeting diagnostic criteria for depression, symptoms such as low mood and reduced interest may progressively improve with continued treatment. Some individuals may consequently feel emotionally lighter or more positive. However, the drug requires time to take effect—typically 2 to 4 weeks—and individual responses to the medication may differ significantly.

If depression has not been clinically diagnosed or if mood fluctuations are due to short-term stress, self-medication may fail to achieve the desired results and could even lead to new issues due to side effects such as headache, nausea, or liver function abnormalities. Moreover, the safety of this medication in children, adolescents, pregnant women, and breastfeeding mothers has not yet been established, so its use in these populations must strictly follow medical advice.

Regular follow-up visits are necessary during treatment to evaluate efficacy and safety. Abrupt discontinuation or dose adjustments should be avoided. If severe mood swings, suicidal thoughts, or serious physical discomfort occur, immediate contact with a healthcare provider is essential.

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