Can levetiracetam tablets and aripiprazole be taken at the same time?

Levetiracetam tablets and aripiprazole may be taken concurrently under the guidance of a physician, but there are risks involved. Combination use must be carefully evaluated based on individual medical conditions and should never be initiated without medical supervision. Detailed analysis is as follows:

Levetiracetam is an antiepileptic drug that stabilizes neuronal activity by modulating central nervous system neurotransmitters; aripiprazole is an antipsychotic that acts on central dopamine and serotonin receptors. Both drugs affect the central nervous system, and their combined use may enhance central inhibitory effects, increasing the risk of adverse effects such as drowsiness, dizziness, difficulty concentrating, slowed reaction time, and in some individuals, mood fluctuations or impaired motor function. As both medications are metabolized through the liver and kidneys, concomitant use may increase the burden on these organs, particularly posing higher risks for patients with pre-existing liver or kidney dysfunction.

In clinical practice, when patients have both epilepsy and psychiatric disorders requiring combination therapy, physicians will thoroughly review the patient’s medical and medication history, precisely adjust dosages, and require regular monitoring of liver and kidney function as well as neurological status. Patients must strictly adhere to medical instructions, document any physical responses, and maintain open communication with their doctor to ensure a proper balance between safety and therapeutic efficacy.