Can people with depression take pre-workout supplements (nitric oxide boosters)?

Nov 21, 2025 Source: Cainiu Health
Dr. Huang Yuhong
Introduction
As a fitness supplement, nitrogen pumps mainly contain ingredients such as caffeine and creatine, which work by increasing nervous system excitability and enhancing physical performance. However, excessive caffeine intake may lead to side effects including rapid heartbeat, insomnia, and anxiety. Since individuals with depression often already experience sleep disturbances and low mood, consuming nitrogen pumps could worsen insomnia symptoms, further disrupt emotional stability, and potentially exacerbate fluctuations in their condition.

Generally, patients with depression are not advised to consume pre-workout supplements (commonly known as "nitrogen pumps"). If any abnormal symptoms occur, it is recommended to seek medical attention promptly. The detailed analysis is as follows:

Pre-workout supplements, often referred to as nitrogen pumps, primarily contain ingredients such as caffeine and creatine, which serve to increase nervous system excitability and enhance physical performance. However, excessive intake of caffeine may lead to side effects including increased heart rate, insomnia, and anxiety. Since individuals with depression commonly experience sleep disturbances and low mood, consuming nitrogen pumps could worsen insomnia and further disrupt emotional stability, potentially causing fluctuations in their condition.

If a patient is in the remission phase of depression, not taking antidepressant medications, and has a good tolerance to caffeine, short-term and limited use of nitrogen pumps might theoretically not cause serious issues. However, this situation is highly exceptional and requires strict risk assessment. In most cases, such use is still not recommended.

Before choosing any health supplements or nutritional products, individuals with depression should always consult a physician or a professional nutritionist. Decisions should be made based on a comprehensive evaluation of their specific condition and medication regimen, avoiding self-administration of products containing stimulants to prevent increased physical strain.