Is it acceptable to add memantine hydrochloride tablets if co-administration of olanzapine and clonazepam is ineffective?

Generally, when olanzapine and clonazepam are taken together without achieving the desired effect, it is not recommended to self-administer memantine hydrochloride tablets. A physician should evaluate the patient's condition and determine the reasons for inadequate efficacy before deciding on any adjustment. If there are concerns, it is advisable to seek medical consultation promptly. Detailed analysis is as follows:

If poor efficacy is due to the current treatment regimen failing to address core symptoms (such as accompanying cognitive impairment), and if the physician determines that the patient’s condition meets the indications for memantine hydrochloride, adding this medication may be considered. However, prior to doing so, a thorough review of the patient's medical history and all concomitant medications is essential to avoid ineffective treatment or increased burden caused by inaccurate clinical assessment.

If inadequate response results from insufficient dosage, inadequate duration of treatment, or undiagnosed underlying health issues (such as abnormal liver or kidney function affecting drug metabolism), physicians may prioritize adjusting the dose or regimen of olanzapine or clonazepam rather than directly adding memantine hydrochloride. Blindly adding medications could mask the true cause and potentially lead to overlapping adverse effects such as drowsiness and dizziness.

During treatment with olanzapine and clonazepam, patients who perceive suboptimal efficacy should promptly consult a doctor and must not self-adjust their medication. When seeking medical advice, patients should clearly report the duration of medication use, dosages, and bodily responses. After any medication adjustment, close monitoring of one's condition is necessary, and any discomfort should be reported to the doctor immediately.