What is the difference between Aitoxin and Suleng Olopatadine Hydrochloride Tablets?

Kitotifen fumarate tablets, marketed as Aitoxin, and Olopatadine hydrochloride tablets (Suling) are both used for allergy treatment but differ in several aspects, including drug class, mechanism of action, indications, adverse effects, and administration methods. The detailed comparison is as follows:

1. Drug Class: Kitotifen fumarate tablets belong to a combination-type medication with both antihistamine and mast cell stabilizing properties, providing dual pharmacological actions. In contrast, Suling olopatadine hydrochloride tablets are selective histamine H1 receptor antagonists that also possess mild mast cell membrane-stabilizing activity, differing in primary classification.

2. Mechanism of Action: Kitotifen fumarate works through a dual pathway—blocking histamine receptors and inhibiting the release of allergic mediators from mast cells—resulting in a relatively gradual onset but prolonged effect. Olopatadine hydrochloride primarily acts by competitively binding to histamine receptors to block allergic reactions, while mildly suppressing the release of allergic mediators, leading to a faster onset of action.

3. Indications: Kitotifen fumarate tablets are commonly used for the prevention and treatment of allergic rhinitis and allergic bronchial asthma, covering a broad range of respiratory allergies. Olopatadine hydrochloride tablets are mainly indicated for allergic rhinitis and allergic conjunctivitis, offering stronger targeting of ocular allergic symptoms, and can also be used for certain skin-related allergic conditions.

4. Adverse Effects: Common side effects of kitotifen fumarate include drowsiness, dry mouth, and fatigue due to central nervous system depression; some individuals may experience weight gain. Olopatadine hydrochloride generally causes milder side effects, such as slight headache, dry mouth, and eye discomfort, with a lower incidence of central nervous system depression, thus having less impact on daily activities.

5. Administration: Kitotifen fumarate is typically administered orally, usually twice daily, with dosage adjusted according to age and condition. In addition to oral tablets, olopatadine hydrochloride is also available in topical formulations such as eye drops. The oral form is usually taken twice daily, while topical forms should be used as directed by a physician based on ocular symptoms.

Before using either medication, it is important to clearly identify the type of allergic condition to avoid inappropriate use. If significant discomfort occurs during treatment, discontinue use immediately and consult a healthcare provider.