What should I do if my fever doesn't subside after taking medication?

Nov 24, 2025 Source: Cainiu Health
Dr. Ren Yi
Introduction
If fever persists despite taking medication, it is important to check whether the medication is being used correctly, ensure adequate fluid intake, apply physical cooling methods, identify the underlying cause, and adjust care strategies accordingly—avoid blindly increasing medication or delaying treatment. Seek medical attention promptly if the fever lasts more than 3 days, body temperature remains above 38.5°C, or is accompanied by severe headache or difficulty breathing.

Fever that does not subside after taking medication requires checking whether the medication is used properly, ensuring adequate fluid intake, using physical cooling methods, identifying the underlying cause, and adjusting care strategies—avoid blindly increasing medication or delaying medical evaluation. If fever persists beyond 3 days, body temperature remains above 38.5°C, or is accompanied by severe headache or difficulty breathing, prompt medical attention is recommended.

1. Check proper medication use: Confirm that the type and dosage of fever-reducing medication are appropriate for age and weight, and that doses are taken at correct intervals. Avoid ineffective fever reduction due to underdosing, irregular administration, or expired medications.

2. Ensure adequate hydration: During fever, metabolic rate increases and fluid loss is significant. Dehydration can impair fever control. Drink plenty of warm water or oral rehydration solutions to promote sweating and urination, aiding in body temperature regulation.

3. Use physical cooling methods: Wipe large blood vessel areas such as the forehead, neck, armpits, and groin with lukewarm water, or apply cooling patches. Avoid alcohol rubs to minimize skin irritation and assist in lowering body temperature.

4. Identify the cause: Fever may result from viral or bacterial infections, or non-infectious factors. If caused by bacterial infection, fever reducers alone will not be effective; anti-infective medications should be used under a doctor’s guidance.

5. Adjust care approach: Maintain good indoor ventilation, avoid excessive clothing or bedding that impairs heat dissipation, ensure sufficient rest, minimize physical activity, and consume light, easily digestible food to support recovery.

Avoid self-administering multiple fever-reducing drugs simultaneously. Follow instructions on labels or as prescribed by a doctor, closely monitor temperature changes, and record fever duration and associated symptoms to provide accurate information for medical evaluation and faster diagnosis.