What are the contraindications of tiopronin for injection?

As a commonly used clinical medication, tiopronin for injection must be strictly administered in accordance with contraindications, including hypersensitivity to its components, use during pregnancy and lactation, severe hepatitis, severe renal insufficiency, and concomitant use with certain specific drugs. A detailed analysis is as follows:

1. Contraindicated in individuals allergic to components: Patients who are allergic to tiopronin or any excipients in the formulation must not use this drug. Allergic reactions may manifest as rash, itching, difficulty breathing, and in severe cases can be life-threatening. Therefore, patients should inform their healthcare provider of any known allergy history before administration.

2. Contraindicated in pregnant and breastfeeding women: This drug can cross the placental barrier and may be excreted in breast milk, potentially causing adverse effects on the fetus or infant, such as impaired growth and development. To ensure maternal and infant safety, its use is strictly prohibited in pregnant and nursing women.

3. Contraindicated in patients with severe hepatitis: In patients with severe hepatitis, liver function is critically impaired, resulting in significantly reduced drug metabolism capacity. Administration of this drug may increase the burden on the liver and lead to worsening of the condition; thus, these patients should avoid using it.

4. Contraindicated in patients with severe renal insufficiency: The drug and its metabolites are primarily excreted through the kidneys. Patients with severe renal impairment have compromised excretory function, which may lead to drug accumulation and increased risk of toxicity and adverse effects. Therefore, this drug is contraindicated in such patients.

5. Contraindicated combinations with certain medications: Concurrent use of this drug with certain other medications may result in adverse interactions. For example, co-administration with chemotherapeutic agents such as cisplatin may increase the risk of nephrotoxicity; when used together with penicillin-class antibiotics, it may reduce efficacy or trigger adverse reactions. Consultation with a physician is required before combining with other drugs.

Prior to clinical use, a thorough review of the patient’s medical and medication history must be conducted to strictly exclude any contraindications. Close monitoring of the patient's physical response is necessary during treatment. If any abnormalities occur, the drug should be discontinued immediately and appropriate interventions taken. Additionally, maintaining a light diet is recommended to support bodily stability.