What are the contraindications of adenosine cyclphosphate for injection?

Under normal circumstances, adenosine cyclophosphate for injection—a drug used to improve myocardial metabolism—has several contraindications, including: hypersensitivity to its components, acute phase of acute myocardial infarction, severe myocardial injury, acute phase of cerebral hemorrhage, and concomitant use with caffeine-containing medications. The details are as follows:

1. Contraindicated in individuals allergic to the drug components: Patients who are allergic to adenosine cyclophosphate or any excipients in the formulation may experience serious reactions such as rash, itching, or anaphylactic shock after administration. Therefore, the drug must not be used. Patients should proactively inform their doctor of any allergy history before treatment to avoid risks.

2. Contraindicated during the acute phase of acute myocardial infarction: Within 24 hours of onset of acute myocardial infarction, the myocardium is in a sensitive state of ischemia and necrosis. The drug may increase myocardial oxygen consumption, exacerbate myocardial damage, and even trigger arrhythmias. Use should only be considered after the condition has stabilized and further evaluation has been performed.

3. Contraindicated in patients with severe myocardial injury: In patients with conditions such as severe myocarditis or myocardial rupture, where myocardial structure and function are already severely compromised, the myocardial-stimulating effect of the drug may exceed the heart's tolerance, leading to worsening of the condition and increased risk of heart failure.

4. Contraindicated during the acute phase of cerebral hemorrhage: Patients in the acute phase of cerebral hemorrhage have poor cerebrovascular stability. The drug may affect cerebrovascular tone or blood pressure regulation, potentially aggravating bleeding or delaying hemostasis. Use should only be considered after bleeding has stopped and the patient’s condition has stabilized, based on physician assessment.

5. Avoid concomitant use with caffeine-containing medications: Caffeine has cardiac stimulant effects. When used together with this drug, the combined myocardial stimulation may lead to tachycardia, arrhythmias, and blood pressure fluctuations. Patients should avoid consuming caffeine-containing drugs or beverages during treatment.

Adenosine cyclophosphate for injection is a prescription medication that must be prescribed by a physician following clinical evaluation. Heart rate, blood pressure, and electrocardiogram should be monitored during treatment. Dosage adjustments are required for elderly patients and those with hepatic or renal impairment. Medication should always be taken strictly as directed; patients must not adjust doses or alter treatment regimens on their own.