What are the symptoms of aztreonam allergy?
Nov 25, 2025
Source: Cainiu Health
Dr. Wang Lei
Introduction
In general, symptoms of allergic reaction to aztreonam mainly include skin rash and itching, respiratory discomfort, angioedema, gastrointestinal disturbances, and anaphylactic shock. If any adverse symptoms occur, it is recommended to seek timely medical treatment at a正规 hospital. Before using aztreonam, inform your doctor of any history of allergies and closely monitor your condition during treatment. Discontinue the drug immediately and seek medical attention if signs of allergy appear.
In general, symptoms of aztreonam allergy mainly include skin rash with itching, respiratory discomfort, angioedema, gastrointestinal disturbances, and anaphylactic shock. If any adverse reactions occur, it is recommended to seek timely medical evaluation and treatment at a正规 hospital. The specific analysis is as follows:
1. Skin Rash with Itching
Aztreonam acts as an allergen that activates the body's immune system, triggering the release of inflammatory mediators such as histamine, which irritate the skin. Allergic individuals may develop scattered or patchy rashes accompanied by significant itching. The rash can vary in appearance, presenting as maculopapular lesions or urticarial wheals, and in severe cases, these rashes may coalesce into larger confluent areas.
2. Respiratory Discomfort
Inflammatory mediators cause congestion and edema of the respiratory mucosa, impairing airway patency. Patients may experience nasal congestion, runny nose, sneezing, as well as chest tightness and wheezing. In severe cases, breathing difficulties may occur, manifesting as rapid breathing or mouth breathing.
3. Angioedema
Allergic reactions increase vascular permeability, allowing fluid to leak into subcutaneous tissues. This commonly affects areas such as the eyelids, lips, and face, presenting as localized swelling and shiny skin. In severe cases, it may interfere with eating or vision.
4. Gastrointestinal Disturbances
The gastrointestinal mucosa becomes functionally disrupted due to inflammatory stimulation. Patients may experience nausea and vomiting, possibly accompanied by abdominal pain and diarrhea. Vomitus typically consists of gastric contents, and diarrhea usually presents as watery stools.
5. Anaphylactic Shock
This is the most severe manifestation, in which a vigorous immune response leads to a sudden drop in blood pressure and circulatory failure. Patients rapidly develop confusion, cold and clammy extremities, and weak pulse; without prompt emergency treatment, this condition can be life-threatening.
Before using aztreonam, patients should inform their doctor of any history of allergies and closely monitor their physical condition during treatment. If allergic symptoms occur, discontinue the drug immediately and seek medical attention—do not attempt self-treatment. Individuals with confirmed allergy should record the drug name and proactively inform healthcare providers in future visits to prevent re-exposure.
