Can I drink alcohol on the second day after taking cephalosporin?

Under normal circumstances, alcohol should not be consumed on the second day after taking cephalosporin antibiotics, and any food or medication containing alcohol must be strictly avoided, as doing so may trigger adverse reactions that could endanger health. The detailed explanation is as follows:

Cephalosporin antibiotics inhibit the metabolic process of alcohol in the body, leading to an accumulation of acetaldehyde and causing a disulfiram-like reaction. This reaction may manifest as facial flushing, headache, dizziness, palpitations, chest tightness; in severe cases, it can lead to difficulty breathing, low blood pressure, confusion, and other symptoms that pose serious health risks.

The metabolism of cephalosporins in the body takes time—typically around 7 days for complete elimination. On the second day after administration, drug concentrations in the body remain relatively high. Consuming alcohol, eating foods containing alcohol, or using alcohol-containing medications at this time may all trigger potential risks.

Alcohol should be avoided during antibiotic treatment and for at least one week after discontinuation. Patients should proactively inform their doctors about their alcohol consumption history and follow medical advice carefully. Attention to dietary restrictions while taking medication is essential—it is a key prerequisite for ensuring medication safety and protecting overall health.