What are the effects of phenylbutazone?

Phenylbutazone has effects including antipyretic and analgesic actions, anti-inflammatory and anti-rheumatic properties, promotion of uric acid excretion, relief of joint swelling and pain, and adjunctive treatment of inflammatory diseases. Its clinical use must strictly follow medical instructions to ensure appropriate indications and avoid misuse. If symptoms such as rash, vomiting, or abnormal liver and kidney function occur after taking the drug, prompt medical attention is recommended.

1. Antipyretic and Analgesic: By inhibiting prostaglandin synthesis, phenylbutazone reduces the sensitivity of the body's temperature-regulating center, alleviating fever symptoms. It also relieves mild to moderate pain, such as headaches, toothaches, and neuralgia.

2. Anti-inflammatory and Anti-rheumatic: It has a strong anti-inflammatory effect and can suppress the release of substances like histamine and bradykinin during inflammatory responses. It is suitable for controlling inflammation in rheumatoid arthritis, rheumatic arthritis, and other rheumatic and autoimmune diseases.

3. Promotion of Uric Acid Excretion: The drug inhibits renal tubular reabsorption of uric acid, thereby increasing uric acid excretion through urine. It serves as an adjunctive treatment for gouty arthritis, especially beneficial for patients with reduced uric acid excretion.

4. Relief of Joint Swelling and Pain: For joint redness, swelling, pain, and limited mobility caused by rheumatism or gout, phenylbutazone rapidly reduces inflammatory reactions, improves joint function, and alleviates patient discomfort.

5. Adjunctive Treatment of Inflammatory Diseases: It can be used as supportive therapy for inflammatory joint conditions such as ankylosing spondylitis and osteoarthritis, helping reduce inflammatory infiltration and relieve pain and stiffness.

Dosage and duration of treatment must strictly follow medical advice. Long-term use should be avoided. Patients should drink plenty of water during treatment to promote metabolism, maintain a light diet avoiding spicy and irritating foods, and undergo regular monitoring of liver and kidney function and blood counts to ensure safe medication use.