What are the contraindications of phenylbutazone?
Contraindications for phenylbutazone include: individuals with known allergies, patients with peptic ulcers, those with severe liver or kidney dysfunction, patients with blood disorders, and pregnant or breastfeeding women. This medication has numerous side effects and must be used strictly according to medical guidelines. Misuse in contraindicated populations or the occurrence of severe adverse reactions warrants prompt medical attention.
1. Contraindicated in allergic individuals: Patients allergic to phenylbutazone or its components may experience allergic reactions such as rash, itching, and difficulty breathing after taking the drug. Severe reactions can be life-threatening; therefore, individuals with hypersensitivity should exercise extreme caution.
2. Contraindicated in peptic ulcer patients: Phenylbutazone irritates the gastric mucosa, exacerbating ulcer damage and potentially leading to complications such as bleeding or perforation. Individuals with a history of gastric or duodenal ulcers should avoid using this medication.
3. Contraindicated in severe hepatic or renal impairment: The drug is metabolized through the liver and kidneys. In patients with severe liver or kidney dysfunction, administration may increase organ burden, lead to drug accumulation, and raise the risk of toxicity.
4. Contraindicated in blood disorder patients: Phenylbutazone may suppress bone marrow hematopoietic function, causing leukopenia and thrombocytopenia. Its use in patients with anemia or granulocytopenia may worsen their condition.
5. Contraindicated in pregnant and breastfeeding women: The drug can cross the placental barrier and affect fetal development, and it may also be excreted in breast milk, posing risks to infants. It must be strictly avoided during pregnancy and lactation.
Medication should be taken under a physician's guidance—do not adjust dosage independently. Avoid alcohol during treatment to reduce gastrointestinal irritation. Regular monitoring of liver and kidney function and complete blood counts is essential to ensure safe use.
