What medication works best for a stuffy nose and runny nose?

Nov 27, 2025 Source: Cainiu Health
Dr. Ren Yi
Introduction
Nasal congestion and excessive nasal discharge are usually caused by colds or rhinitis. Appropriate medications should be selected based on the underlying cause. Commonly used drugs include decongestants, antihistamines, intranasal corticosteroids, compound cold medicines, and traditional Chinese patent medicines. For example, oxymetazoline hydrochloride nasal drops can quickly constrict blood vessels in the nasal cavity, reduce swelling of the nasal mucosa, and effectively relieve nasal congestion with a rapid onset of action.

Nasal congestion and runny nose are usually caused by colds or rhinitis. Appropriate medications should be selected based on the underlying cause. Commonly used drugs include decongestants, antihistamines, intranasal corticosteroids, compound cold medicines, and traditional Chinese patent medicines. The details are as follows:

1. Decongestants: For example, oxymetazoline hydrochloride nasal drops. These work quickly to constrict blood vessels in the nasal cavity, reduce swelling of the nasal mucosa, and relieve nasal congestion. They take effect rapidly, but should not be used continuously for more than 7 days to avoid rebound nasal mucosal congestion.

2. Antihistamines: For example, loratadine tablets. Suitable for nasal congestion and clear watery discharge caused by allergic rhinitis, these drugs suppress allergic reactions and reduce nasal mucosal edema. They also help alleviate symptoms such as nasal itching and sneezing, with minimal sedative effects.

3. Intranasal corticosteroids: For example, budesonide nasal spray. These reduce inflammation of the nasal mucosa and help relieve nasal congestion and runny nose. They are suitable for long-term use in patients with chronic rhinitis or allergic rhinitis. Use should follow instructions carefully, and side effects are relatively rare.

4. Compound cold medicines: For example, compound pseudoephedrine hydrochloride sustained-release capsules. These contain both decongestants and antihistamines, effectively relieving nasal congestion and runny nose, while also reducing other cold-related discomforts such as sore throat and headache. Care should be taken to avoid using multiple products containing the same active ingredients simultaneously.

5. Traditional Chinese patent medicines: For example, Tongqiao Biyan tablets. These have effects of dispelling wind, reducing inflammation, and opening nasal passages. They are suitable for nasal congestion and thick nasal discharge caused by rhinitis or colds. With mild action, they can help improve nasal airflow and serve as an auxiliary option for daily symptom relief.

Before using any medication, it is important to identify the cause of nasal congestion and runny nose to avoid inappropriate treatment. Always follow the drug instructions or medical advice strictly, paying attention to dosage and contraindications.