Is long-term use of adapalene gel harmful?

Generally, long-term use of adapalene gel can be harmful, and it is not recommended for prolonged use. The detailed analysis is as follows:

Long-term use of adapalene gel may easily damage the skin barrier, leading to thinning of the stratum corneum and causing persistent dryness and flaking. It can also increase skin sensitivity, frequently resulting in discomfort such as redness, stinging, and itching. The cumulative irritative effect of the medication may reduce the skin's defense against ultraviolet radiation, increasing the risk of tanning and sunburn. In some individuals, prolonged use may lower the skin’s tolerance threshold, potentially triggering or worsening inflammatory reactions—contrary to the intended therapeutic purpose. Typically, after symptoms improve, dosage should be gradually reduced or discontinued according to medical advice, avoiding indefinite or blind long-term application.

In daily skincare, emphasis should be placed on repairing the skin barrier. Use gentle cleansers and avoid over-cleansing. After washing the face, promptly apply a moisturizer containing ceramides and hyaluronic acid to replenish skin moisture and lipids. Strict sun protection during daytime is essential: use sunscreen with SPF 30 and PA+++ or higher, combined with physical sun protection measures to minimize UV damage. Maintain a light diet rich in vitamin-containing foods, and avoid spicy or irritating foods to help sustain healthy skin condition.