How long does an allergic rash to hydroxychloroquine take to resolve?

In general, the time it takes for a rash caused by hydroxychloroquine allergy to resolve varies from person to person and depends on the severity of the allergic reaction and whether intervention is timely. For mild allergies with prompt discontinuation of the drug and appropriate management, the rash typically resolves within 1–2 weeks. However, in cases of severe allergic reactions or delayed treatment, resolution may take several weeks or longer, sometimes requiring extended therapy.

If symptoms are mild—limited to scattered red patches and slight itching—stopping hydroxychloroquine immediately and practicing proper skin care allows the body's immune system to gradually eliminate the allergen. Applying mild topical anti-allergy ointments, while avoiding scratching or irritation, usually leads to gradual fading and resolution of the rash within 1–2 weeks, without leaving noticeable marks.

When the rash covers a large area and is accompanied by significant swelling, intense itching, blisters, or skin breakdown, this indicates a more severe allergic reaction. In such cases, oral antihistamines or other anti-allergy medications should be used under medical supervision, and the recovery period may extend to 2–4 weeks. Without timely control, secondary skin infections may develop, further prolonging the healing process.

Once an allergic rash appears, the first step is to discontinue the offending medication. Keep the skin clean and dry, wear loose, breathable clothing to minimize friction, avoid spicy and irritating foods, and increase intake of vitamin-rich foods to support skin repair.