What should I do if I feel a burning sensation after applying mupirocin ointment?

Mupirocin ointment may cause a burning sensation after application. This discomfort can be managed by immediately discontinuing the medication and washing the area, applying cold compresses, avoiding irritation to the affected area, monitoring symptom changes, or switching to an alternative medication. These reactions are usually due to local irritation or mild allergic responses. If the burning sensation is severe, accompanied by redness, rash, or worsening symptoms, prompt medical attention is recommended.

1. Discontinue medication and wash: Stop using mupirocin ointment and gently clean the applied area with lukewarm water to remove any residual ointment, reducing continued skin irritation. Avoid rubbing the affected area vigorously during cleaning.

2. Cold compress to relieve discomfort: Wrap an ice pack in a clean towel and apply it as a cold compress to the affected area for 10–15 minutes per session. This helps constrict blood vessels and reduce the burning sensation and swelling. Be careful not to place ice directly on the skin.

3. Avoid irritating the affected area: Do not scratch or rub the affected site. Avoid using skincare products or ointments containing alcohol or fragrances. Wear loose, breathable cotton clothing to minimize friction and irritation.

4. Monitor symptom changes: Pay attention to the duration of the burning sensation and changes in skin condition. If symptoms gradually subside within 30 minutes to one hour, there is generally no need for concern. However, if symptoms persist or worsen, timely intervention is necessary.

5. Switch to an alternative medication: If drug intolerance is confirmed, consider switching to another type of antibacterial ointment under professional guidance. Avoid changing medications arbitrarily without medical advice to prevent delays in treatment.

Keep the affected area clean and dry. Maintain a light diet and avoid spicy or irritating foods. Drink plenty of water to support metabolism. Before future use of topical medications, perform a patch test on a small area (e.g., behind the ear) to observe for any adverse reactions and ensure skin tolerance before broader application.