What medication is best for non-gonococcal urethritis patients to recover the fastest?

Nov 29, 2025 Source: Cainiu Health
Dr. Cao Zhiqiang
Introduction
Non-gonococcal urethritis (NGU) usually refers to non-gonococcal urethritis. Commonly used medications for NGU include azithromycin, doxycycline, minocycline, levofloxacin, and erythromycin. The choice of medication should be based on the type of pathogen and drug susceptibility test results, and must be made under medical guidance; self-medication is not recommended. If symptoms such as increased urinary frequency, urgency, dysuria, or abnormal increase in urethral discharge occur, prompt medical attention is advised.

Non-gonococcal urethritis (NGU) is commonly referred to as non-gonorrheal urethritis. Commonly used medications for NGU include azithromycin, doxycycline, minocycline, levofloxacin, and erythromycin. The choice of medication should be based on the type of pathogen and drug sensitivity test results under medical guidance; self-medication is not recommended. If symptoms such as increased urinary frequency, urgency, dysuria, or abnormal increase in urethral discharge occur, prompt medical attention is advised.

1. Azithromycin: This drug has strong inhibitory effects against pathogens such as mycoplasma and chlamydia, and is one of the first-line treatments in clinical practice. It is suitable for uncomplicated non-gonococcal urethritis, with a broad antimicrobial spectrum and long-lasting action.

2. Doxycycline: A tetracycline-class antibiotic that effectively kills mycoplasma and chlamydia, and also shows certain efficacy against drug-resistant strains. It is suitable for complicated or recurrent cases of non-gonococcal urethritis.

3. Minocycline: More potent than doxycycline, it is effective against various pathogenic bacteria and can be used to treat non-gonococcal urethritis caused by mycoplasma and chlamydia, especially suitable for patients who are less responsive to other antibiotics.

4. Levofloxacin: A fluoroquinolone antibiotic that works by inhibiting pathogen DNA replication. It is effective against mycoplasma, chlamydia, and some bacterial infections, making it suitable for patients with mild concurrent urinary tract infections.

5. Erythromycin: A macrolide antibiotic that inhibits mycoplasma and chlamydia. It is suitable for patients allergic to or intolerant of azithromycin. Clinical use should be adjusted according to individual patient conditions.

During treatment, maintain cleanliness and dryness of the external genital area, wash daily with warm water, and avoid sexual activity to prevent cross-infection. Follow a light diet, avoid spicy and irritating foods, drink plenty of water, and urinate frequently to flush the urethra. Maintain regular作息 (daily routines), avoid staying up late, and enhance physical immunity to support recovery.