How long does it take for mycoplasma positive to turn negative?

Dec 01, 2025 Source: Cainiu Health
Dr. Ren Yi
Introduction
Mycoplasma positivity usually turns negative within 1–3 months after standardized treatment. Some asymptomatic individuals may clear the infection spontaneously. The specific duration depends on the infected site, treatment effectiveness, and individual immune status. If the test remains positive for more than 3 months or is accompanied by significant symptoms, timely medical consultation is recommended to adjust the treatment plan. Respiratory mycoplasma infection can be treated with sensitive antibiotics.

  A positive mycoplasma result usually turns negative within 1–3 months after standardized treatment. Some asymptomatic carriers may clear the infection spontaneously. The specific duration depends on the infected site, treatment effectiveness, and individual immune function. If the test remains positive for more than three months or is accompanied by obvious symptoms, timely medical consultation is recommended to adjust the treatment plan.

  For respiratory mycoplasma infections, symptoms typically improve within 1–2 weeks after treatment with sensitive antibiotics. Nucleic acid or antibody tests may take 1–2 months to turn negative, though in individuals with weaker immunity, this may extend up to 3 months. Genitourinary mycoplasma infections require a slightly longer treatment course; with proper medication, conversion to negative status generally takes 2–3 months. Incomplete treatment should be avoided to prevent recurrence.

  Patients who do not receive standardized treatment, have drug-resistant strains, or suffer from co-infections may experience significantly prolonged clearance times, potentially remaining positive indefinitely. Asymptomatic carriers generally do not require aggressive intervention—most can clear the infection naturally within 3 months by boosting their immunity, but regular follow-up testing is necessary to monitor their status.

  Maintain a regular daily routine and avoid staying up late. Eat a balanced diet rich in protein and vitamins, and engage in moderate exercise to strengthen immunity. Respiratory infection patients should wear masks to prevent cross-infection, while those with genitourinary infections should abstain from sexual activity during treatment to minimize irritants and support recovery.