What medication can quickly lower transaminase levels?

Dec 02, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Drugs that can rapidly lower transaminase levels mainly include glycyrrhizin preparations, silybin, polyene phosphatidylcholine, bifendate tablets, and biphenyl dimethyl dicarboxylate droplets. These should be used appropriately according to the underlying cause of elevated transaminases; self-medication without medical guidance is not recommended. If transaminase levels remain elevated or are accompanied by symptoms such as fatigue and jaundice, prompt medical evaluation is advised to determine the underlying cause.

Medications that can rapidly lower transaminase levels mainly include glycyrrhizin preparations, silybin agents, polyene phosphatidylcholine, bifendate tablets, and biphenyl dimethyl dicarboxylate drops. These should be used under medical guidance according to the underlying cause of elevated transaminases. Self-medication without medical advice is not recommended. If transaminase levels remain elevated or are accompanied by symptoms such as fatigue or jaundice, prompt medical evaluation is advised to determine the cause.

1. Glycyrrhizin preparations: Exert anti-inflammatory effects and protect hepatocyte membranes, thereby reducing liver cell damage and rapidly lowering both alanine aminotransferase (ALT) and aspartate aminotransferase (AST). They are suitable for transaminase elevation caused by viral hepatitis or drug-induced liver injury.

2. Silybin agents: Extracted from milk thistle, these enhance liver cell repair and eliminate free radicals, reducing transaminase levels while improving hepatic inflammation. They are appropriate for liver damage due to chronic hepatitis or fatty liver disease.

3. Polyene phosphatidylcholine: Replenishes components of hepatocyte membranes, promotes regeneration of damaged liver cells, reduces transaminase levels, and alleviates hepatic steatosis. It is commonly used as an adjunctive treatment for alcoholic liver injury and toxic hepatitis.

4. Bifendate tablets: Protect hepatocytes and inhibit the release of transaminases, effectively lowering enzyme levels. Suitable for transaminase elevation caused by various types of chronic hepatitis, they should be taken for the full prescribed course to prevent rebound elevation.

5. Biphenyl dimethyl dicarboxylate drops: Specifically target elevated ALT with rapid enzyme-lowering effects. Indicated for transaminase increases due to hepatitis or exposure to drugs and chemical substances. Dosage should be gradually tapered after treatment to prevent relapse.

During medication, strictly follow the doctor's instructions regarding dosage; do not adjust or discontinue the medication on your own. Maintain a light, low-fat diet, avoid alcohol and smoking to reduce metabolic burden on the liver. Keep regular作息 (daily routines), avoid staying up late and overexertion, and have liver function tests regularly to monitor changes in liver parameters.