Does elevated cytomegalovirus IgG have an impact on pregnancy?

Generally, the impact of elevated cytomegalovirus (CMV) IgG levels on pregnancy depends on the status of IgM. If IgM is negative, there is usually no significant impact; however, if IgM is positive, caution is warranted. In case of concerns, it is recommended to seek medical advice in advance. Detailed analysis is as follows:

If CMV IgG levels are elevated and IgM is negative, this indicates a past infection with development of antibodies and suggests the body has acquired certain immunity. This situation typically does not adversely affect pregnancy, as the risk of re-infection during pregnancy is low. No special treatment is required, and individuals can normally prepare for pregnancy or continue with their current pregnancy.

If CMV IgG levels are elevated and IgM is positive, it may indicate a recent or reactivated infection. If this occurs during pregnancy, the virus could cross the placenta and affect the fetus, increasing risks such as miscarriage or fetal malformations. In such cases, pregnancy should be postponed or closely monitored, and conception planned only after IgM becomes negative.

After detecting elevated CMV IgG levels, results should be interpreted in combination with IgM findings. If abnormalities are found during preconception preparation or pregnancy, timely follow-up testing is advised. Practicing good hand hygiene and avoiding contact with secretions from infected individuals can help reduce the risk of viral exposure.