Yellow fever virus has several serotypes.

Yellow fever virus has only one serotype. Although there are certain genetic differences among different strains, the antigenicity is highly consistent, with no obvious serotype differentiation, providing an important foundation for vaccine development and immune protection. If symptoms such as fever, jaundice, and muscle pain occur, medical attention is recommended promptly.

Yellow fever virus belongs to the genus Flavivirus in the family Flaviviridae. Its single serotype characteristic means that antibodies generated through infection or vaccination can provide cross-protection against yellow fever virus strains worldwide, eliminating the need to develop region-specific vaccines targeting different local strains.

This antigenic consistency stems from the high conservation of the viral envelope protein, where key antigenic sites remain unchanged, enabling the host immune system to effectively recognize the virus and produce neutralizing antibodies. This is also a key reason why the yellow fever vaccine maintains high protective efficacy over a long period.

To reduce infection risk, avoid traveling to areas where yellow fever is endemic. When travel is necessary, get vaccinated in advance, wear long-sleeved clothing, use insect repellent to prevent mosquito bites, and maintain clean living environments to minimize mosquito breeding.