How to manage yellow skin in individuals with "small three positives" (a pattern of hepatitis B virus markers)

Dec 02, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Skin yellowing in individuals with "small three positives" (chronic hepatitis B with specific serological markers) requires management through addressing the underlying cause, standardized medication, dietary adjustments, improved daily routines, and close monitoring of disease progression. The key goals are protecting liver cells and promoting bilirubin metabolism. If skin yellowing progressively worsens or is accompanied by fatigue and abdominal distension, prompt medical attention is necessary. Clarify the hepatitis B virus replication status; if viral load is high, follow

For individuals with "small three positives" (chronic hepatitis B surface antigen, e antigen negative, and core antibody positive) who experience yellowing of the skin, management should focus on treating the underlying cause, standardized medication use, dietary adjustments, improved lifestyle habits, and regular monitoring of disease progression. The key goals are protecting liver cells and promoting bilirubin metabolism. If skin yellowing worsens progressively or is accompanied by fatigue and abdominal distension, prompt medical attention is necessary.

1. Treat the Underlying Cause: Assess viral replication activity in small three positives. If viral load is high, follow medical advice to undergo antiviral therapy, thereby reducing hepatocyte damage at its source and preventing bilirubin accumulation.

2. Standardized Medication Intervention: Use liver-protective and jaundice-relieving medications under a physician's guidance. Avoid self-medicating, which may increase the liver’s burden, and ensure treatment is both safe and effective.

3. Adjust Diet Structure: Focus on light, easily digestible foods. Increase intake of high-quality protein and vitamins while avoiding greasy, spicy, and high-fat foods to reduce metabolic stress on the liver.

4. Improve Lifestyle Habits: Ensure adequate sleep and avoid staying up late. Prevent excessive physical strain, quit smoking and drinking alcohol to minimize further liver cell injury and create favorable conditions for liver repair.

5. Monitor Disease Progression: Regularly recheck liver function tests and viral load to track changes in condition promptly. This allows doctors to adjust treatment plans timely and prevent disease progression.

In daily life, maintain a regular routine, engage in moderate light exercise to strengthen physical health, eat a balanced diet without overeating, and keep a positive mood to reduce emotional fluctuations that may negatively affect the liver, thus supporting liver cell recovery and overall healing.