What is the difference between "big three positive" and "big two positive," and which one is more severe?

Compared to "Big Two Positive," "Big Three Positive" indicates a relatively more severe condition. Both statuses suggest active hepatitis B virus infection with active viral replication, but "Big Three Positive" is associated with more intense viral replication, higher infectivity, and a greater risk of progressing to cirrhosis and liver cancer. Close monitoring and timely intervention are therefore essential. If symptoms such as fatigue, dark urine, or discomfort in the liver area occur, prompt medical attention is recommended.

"Big Three Positive" refers to positive results for hepatitis B surface antigen, e-antigen, and core antibody. It is typically associated with higher viral load, and persistent viral replication can lead to repeated liver cell damage. Without timely intervention, the risk of developing liver fibrosis and cirrhosis increases over time.

"Big Two Positive" means only hepatitis B surface antigen and e-antigen are positive, without the core antibody marker. Although viral activity and infectivity are slightly lower than in "Big Three Positive," if accompanied by persistently abnormal liver function, it may still rapidly progress to severe liver disease and should not be ignored.

In daily life, it's important to maintain regular作息 (sleep patterns), avoid staying up late, eat a light diet avoiding greasy food and alcohol to reduce the burden on the liver, regularly recheck liver function and hepatitis B virus DNA, engage in moderate and gentle exercise to strengthen physical health, and maintain emotional stability to support liver health.