What does it mean if liver function tests show low alkaline phosphatase?

Dec 02, 2025 Source: Cainiu Health
Dr. Gao Jun
Introduction
Low alkaline phosphatase in liver function tests may be caused by inadequate nutrition, poor physical condition, hypothyroidism, anemia, or chronic kidney disease. It can be improved through nutritional supplementation, strengthening the body, and medical treatment. If levels remain persistently low or are accompanied by symptoms such as fatigue or dizziness, prompt medical attention is necessary. Prolonged picky eating or a vegetarian diet may lead to this condition.

Low levels of alkaline phosphatase in liver function tests may be caused by inadequate nutrition, physical weakness, hypothyroidism, anemia, or chronic kidney disease. These can be improved through nutritional supplementation, strengthening the body, and medical treatment. If enzyme levels remain persistently low or are accompanied by symptoms such as fatigue and dizziness, prompt medical evaluation is recommended.

1. Inadequate dietary nutrition: Long-term picky eating or a strict vegetarian diet may lead to insufficient intake of calcium, phosphorus, and protein, affecting enzyme synthesis and possibly causing limb weakness. It is recommended to maintain a balanced diet with increased consumption of milk, eggs, lean meat, and other nutrient-rich foods to support enzyme production.

2. Physical weakness: Prolonged lack of exercise and irregular作息 (lifestyle) can slow down metabolism and reduce enzyme activity, often accompanied by low energy and decreased immunity. It is advised to maintain regular作息 (sleep-wake cycles) and engage in moderate activities such as walking or yoga to strengthen the body and improve metabolic function.

3. Hypothyroidism: Insufficient secretion of thyroid hormones suppresses overall metabolism, leading to reduced synthesis of alkaline phosphatase. Symptoms may include cold intolerance, weight gain, and memory decline. Under medical guidance, patients may take medications such as levothyroxine sodium tablets, thyroid tablets, or liothyronine sodium tablets to alleviate symptoms.

4. Anemia: Deficiency in hematopoietic materials or impaired blood cell production affects bone marrow and liver cell function, resulting in low alkaline phosphatase levels. This condition may be accompanied by pallor, dizziness, and palpitations. Under medical supervision, patients may use ferrous sulfate tablets, iron succinate oral solution, or vitamin B12 injections to relieve symptoms.

5. Chronic kidney disease: Impaired kidney filtration and metabolic functions disrupt the body's internal balance, indirectly reducing enzyme synthesis. Symptoms may include lower limb edema and abnormal urine output. As directed by a physician, medications such as Yuduqing granules, Shenshuaining tablets, or sodium bicarbonate tablets may be used to manage symptoms.

Maintain a balanced and varied diet rich in high-quality protein, calcium, phosphorus, and vitamins. Keep regular作息 (sleep habits), avoid staying up late, engage in moderate exercise to strengthen the body, avoid misuse of medications, and have liver function regularly rechecked to monitor changes and support recovery.