Is an alanine aminotransferase (ALT) level of 60 serious for a hepatitis B patient?

Generally, the severity of an ALT (alanine aminotransferase) level of 60 in patients with hepatitis B depends on the persistence of this value and the status of the virus. Short-term fluctuations are usually not serious, but persistent elevation should raise concern. If in doubt, it is recommended to seek medical advice promptly. Detailed analysis is as follows:

If the ALT level of 60 appears temporarily and hepatitis B virus DNA test results are negative, without accompanying symptoms such as abnormal bilirubin levels or discomfort in the liver area, the elevation may be related to recent factors like staying up late, alcohol consumption, or fatigue. This situation typically represents a transient, mild increase due to minor liver inflammation, which may normalize through lifestyle adjustments and is generally not considered serious.

However, if ALT remains at 60 or above for more than three months, or if hepatitis B virus DNA is positive—even in the absence of obvious symptoms—it may indicate ongoing low-grade liver inflammation. Over time, this can lead to hepatocyte necrosis and fibrosis. Follow-up data show that some patients with such conditions may progress to significant fibrosis within a few years. Therefore, this scenario should be taken seriously and not regarded as a minor issue.

When a hepatitis B patient has an ALT level of 60, timely evaluation of hepatitis B virus DNA and liver stiffness measurement (liver elasticity) is necessary. Alcohol consumption and late-night habits should be avoided to reduce liver burden. Patients must strictly follow medical advice and, when necessary, initiate antiviral therapy to prevent disease progression.