Is an alpha-fetoprotein level over 50 serious?

Alpha-fetoprotein (AFP) levels over 50 represent a mild elevation, which is not extremely severe but requires serious attention. The normal reference value for AFP in healthy adults is generally below 25 ng/ml; this result exceeds the normal range and may be associated with liver diseases, germ cell tumors, or other conditions, although benign factors could also contribute. If symptoms such as abdominal pain or jaundice are present, prompt medical evaluation and further testing are recommended.

Alpha-fetoprotein is an important tumor marker for liver cancer. Elevated AFP levels are commonly seen in primary hepatocellular carcinoma, but a level slightly above 50 is not specific to liver cancer—benign liver conditions such as chronic hepatitis and liver cirrhosis may also cause mild elevations due to hepatocyte damage and regeneration.

In addition, germ cell tumors such as ovarian or testicular cancer, as well as non-pathological factors like pregnancy, intense physical exercise, or alcohol consumption, can lead to transient increases in AFP. A single elevated value cannot confirm a diagnosis; comprehensive assessment including imaging studies and clinical symptoms is necessary.

In daily life, it is important to quit smoking and avoid alcohol, refrain from consuming greasy or spicy foods to reduce liver strain, maintain regular sleep patterns without staying up late, engage in moderate and gentle exercise, keep emotional balance, and follow medical advice for regular AFP monitoring and related examinations to track changes in levels.