What causes recurrent blisters on the foreskin of the penis, and what should be done about it?
Dec 03, 2025
Source: Cainiu Health
Dr. Liu Wenmin
Introduction
In general, recurrent blisters on the penis may be caused by friction, improper hygiene, genital herpes, contact dermatitis, or balanoposthitis. Appropriate measures such as general care or medication can be chosen based on the specific situation. Daily attention should be paid to external genital care, using gentle cleaning methods and avoiding contact with suspected irritants.
Generally, recurrent blisters on the foreskin or penis may be caused by friction irritation, poor hygiene, genital herpes, contact dermatitis, or balanoposthitis. Depending on the specific situation, improvements can be achieved through general care, medication, or other treatments. Detailed analysis is as follows:
1. Friction Irritation
Tight clothing or frequent rubbing can damage the local skin, causing tissue fluid to leak and form blisters. It is recommended to wear loose, breathable cotton underwear, avoid prolonged sitting, and reduce local pressure and friction.
2. Poor Hygiene
Accumulation of sweat and secretions over time can irritate the skin, leading to localized inflammation and blister formation. Wash the external genital area daily with warm water, keep it dry and clean, and avoid using irritating cleansing products.
3. Genital Herpes
Caused by infection with the herpes simplex virus (HSV), which remains latent in nerve ganglia and becomes active when immunity is reduced, damaging the skin and mucous membranes to form blisters. Under medical guidance, antiviral medications such as acyclovir tablets, valacyclovir tablets, or famciclovir capsules may be taken. Avoid scratching the affected area.
4. Contact Dermatitis
Exposure to allergens such as condoms or lubricants triggers an allergic skin reaction, resulting in blisters accompanied by itching. As directed by a physician, topical treatments like mometasone furoate cream or hydrocortisone butyrate cream, and oral antihistamines such as loratadine tablets may be used. Avoid known allergens.
5. Balanoposthitis
Long foreskin can lead to bacterial growth and subsequent inflammation, which irritates the skin and mucous membranes, causing blisters and redness. Under medical supervision, topical antibiotics such as erythromycin ointment or mupirocin ointment may be applied, and oral cephalosporins like cefuroxime axetil tablets may be prescribed. For individuals with phimosis, circumcision may be considered.
It is important to maintain proper genital hygiene in daily life, use gentle cleaning methods, and avoid exposure to suspected irritants. If blisters recur or are accompanied by pain, fever, or other symptoms, seek medical attention promptly for accurate diagnosis. Do not self-medicate to ensure safe and effective treatment.
