How high does gamma-glutamyl transferase (GGT) need to be to require treatment?

　　The normal reference range for γ-glutamyl transferase (GGT) is generally 0–50 U/L. When levels exceed 100 U/L—twice the upper limit of normal—and remain elevated, the underlying cause should be promptly identified and treatment initiated. For mild elevations, potential triggers should be evaluated first, and immediate medication is usually not required. If GGT levels persistently exceed 200 U/L or are accompanied by symptoms such as jaundice or abdominal pain, timely medical consultation is recommended.

　　γ-Glutamyl transferase is primarily present in the liver and biliary system. Mild elevations may be related to lifestyle factors such as alcohol consumption, lack of sleep, or a high-fat diet; these often return to normal after appropriate adjustments. Levels exceeding 100 U/L suggest possible liver or biliary damage, such as fatty liver disease, bile duct obstruction, or hepatitis.

　　The higher the value and the longer it remains elevated, the more significant the pathological implications. In particular, when levels exceed 200 U/L, conditions such as cirrhosis or cholangitis should be suspected. Prompt evaluation through comprehensive liver function tests, liver and biliary ultrasound, and other examinations is essential to identify the cause and prevent delayed treatment.

　　Maintaining regular daily routines and avoiding late nights, strictly limiting alcohol intake, adopting a light diet with reduced consumption of high-fat and high-sugar foods, engaging in moderate physical activity to manage body weight, avoiding self-administered medications that may harm the liver, and undergoing regular liver function tests to monitor changes are all important steps to help restore GGT levels to normal.