What are the efficacy and effects of Acyclovir cream?

Dec 03, 2025 Source: Cainiu Health
Dr. Liu Wenmin
Introduction
As a topical antiviral medication, acyclovir cream exerts its therapeutic effects primarily through anti-herpesvirus activity, treating herpes zoster, relieving symptoms of simple herpes, inhibiting viral replication, and promoting healing of herpes lesions. This medication is intended for use on skin and mucous membranes only and should avoid contact with the eyes. It is contraindicated in individuals allergic to acyclovir. Pregnant and breastfeeding women should use it with caution. Keep the affected area clean and dry during treatment.

As a topical antiviral medication, acyclovir cream's efficacy and functions mainly include anti-herpesvirus activity, treating herpes zoster, relieving symptoms of simple herpes, inhibiting viral replication, and promoting healing of herpes lesions. The specific details are as follows:

1. Anti-herpesvirus effect: The drug has specific inhibitory effects against varicella-zoster virus and herpes simplex virus. It interferes with viral DNA polymerase, preventing virus reproduction within cells, thus specifically targeting pathogenic viruses.

2. Treatment of herpes zoster: Suitable for symptoms caused by herpes zoster such as skin blisters and pain. After application, the medication acts directly on the affected area, reducing viral damage to nerves and skin, and alleviating burning-like pain.

3. Relief of herpes simplex symptoms: Effective in treating herpes simplex infections such as oral herpes and genital herpes. It helps reduce symptoms like blister rupture and erosion, decreases pain and itching, and improves patient comfort.

4. Inhibition of viral replication: After penetrating the skin, the drug precisely targets virus-infected cells, inhibits viral DNA synthesis, prevents increase in viral load, and avoids further spread of infection.

5. Promotion of herpes healing: By controlling viral infection and reducing inflammatory response, it creates a favorable environment for lesion recovery, accelerates drying and crusting of blisters, shortens disease duration, and reduces the risk of secondary infection.

This medication is intended for use on skin and mucous membranes only; avoid contact with eyes. It is contraindicated in individuals allergic to acyclovir. Pregnant and breastfeeding women should use it cautiously. Keep the affected area clean and dry during treatment, and strictly follow medical instructions.

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