What are the efficacy and effects of Ornidazole tablets?

As a commonly used nitroimidazole antibacterial agent, the efficacy and functions of Oronidazole tablets mainly include anti-anaerobic bacterial infection, treatment of trichomoniasis, management of amoebiasis, prevention of postoperative infections, and inhibition of pathogen replication. The detailed analysis is as follows:

1. Anti-anaerobic bacterial infection: Oronidazole tablets have potent bactericidal effects against various anaerobic bacteria, such as *Bacteroides fragilis* and *Clostridium* species. By disrupting the DNA structure of bacteria, it inhibits their activity and is effective in treating anaerobic infections like periodontitis, pelvic inflammatory disease, and peritonitis, thereby alleviating inflammatory symptoms.

2. Treatment of trichomoniasis: The drug is highly effective against infections caused by organisms such as *Trichomonas vaginalis*, making it a common choice for treating trichomonas vaginitis. After oral administration, it acts directly on the parasites, blocking their metabolism and reproduction, improving symptoms such as genital itching and abnormal discharge. Sexual partners should also receive concurrent treatment to prevent recurrence.

3. Management of amoebiasis: Oronidazole can treat both intestinal and extraintestinal amoebiasis, including amoebic liver abscess. It precisely targets *Entamoeba histolytica*, suppressing its growth and eliminating the parasite, thus relieving associated symptoms such as abdominal pain, diarrhea, and liver area tenderness.

4. Prevention of postoperative infection: Prior to surgeries with high risk of anaerobic infection—such as gastrointestinal or gynecological procedures—administration of this medication helps prevent postoperative infections. By preemptively suppressing potential anaerobic bacteria, it reduces the likelihood of infection and supports patient recovery after surgery.

5. Inhibition of pathogen replication: Once absorbed into the body, the drug interferes with DNA synthesis in bacteria and protozoa, effectively halting their reproduction at the root. This prevents an increase in pathogen load and subsequent spread of infection, creating favorable conditions for the body to eliminate pathogens.

This medication must be used strictly according to medical instructions, with clear dosage and duration. It is contraindicated in individuals allergic to nitroimidazole drugs. Alcohol and alcoholic beverages should be avoided during treatment.