What should I do if two liver function indicators are above normal limits?

Generally, elevated levels in two liver function indicators may be caused by excessive alcohol consumption, staying up late, non-alcoholic fatty liver disease, drug-induced liver injury, viral hepatitis, and other factors. It is recommended to seek medical attention promptly, identify the underlying cause, and follow a doctor's guidance for improvement through general management, medication, or other treatments. The specific analysis is as follows:

1. Excessive alcohol consumption: Alcohol is primarily metabolized in the liver, and its metabolite acetaldehyde is highly toxic. It can directly damage the cell membranes of hepatocytes, leading to cell necrosis or degeneration, thereby causing abnormal liver function tests. Immediately stop drinking alcohol. For mild elevations, abstain from alcohol for 1–2 weeks before rechecking. Avoid consuming any alcoholic beverages in daily life.

2. Staying up late and overexertion: The liver enters a period of active metabolism between 11 PM and 3 AM. Chronic sleep deprivation disrupts this process, impairing hepatocyte repair. Excessive physical strain accelerates overall metabolism, increasing the liver’s detoxification burden and causing fluctuations in liver function markers. Maintain regular sleep patterns, ensure 7–8 hours of sleep per night, avoid sleeping after midnight, and reduce heavy physical labor and prolonged熬夜 (staying up late).

3. Non-alcoholic fatty liver disease: Long-term high-fat diet and obesity can lead to excessive fat accumulation within hepatocytes, forming fat droplets that compress normal liver cells, impairing their function and triggering inflammation, which results in elevated liver enzymes. Follow your doctor’s advice to use medications such as silibinin capsules, polyene phosphatidylcholine capsules, or diammonium glycyrrhizinate enteric-coated capsules for treatment.

4. Drug-induced liver injury: Many drugs, including certain antibiotics and lipid-lowering agents, are metabolized in the liver. Their intermediate metabolites may be toxic to hepatocytes or trigger allergic reactions that damage liver cells, resulting in abnormal liver function. Immediately discontinue any suspected medication and, under medical supervision, use liver-protective agents such as reduced glutathione tablets, tiopronin enteric-coated tablets, or compound glycyrrhizin tablets to support liver recovery.

5. Viral hepatitis: Hepatitis B or C viruses specifically target hepatocytes after entering the body, replicate inside the cells, destroy their structure, and provoke immune responses that cause inflammation and necrosis of liver cells, leading to elevated liver function indicators. Patients with hepatitis B can follow medical advice to take entecavir tablets, tenofovir disoproxil fumarate tablets, lamivudine tablets, and other antiviral medications to improve symptoms.

Avoid taking unregulated supplements with unknown ingredients. Increase intake of fresh fruits, vegetables, and high-quality protein. Regularly recheck liver function to monitor changes in indicators, and adopt scientifically sound lifestyle adjustments to reduce liver burden and promote normalization of liver function.