How long does it take for transaminase to decrease from 78 to 40?

Under normal circumstances, it takes 1 to 4 weeks for transaminase levels to decrease from 78 U/L to 40 U/L, with the exact duration varying depending on the underlying cause and treatment measures. If abnormalities are detected, prompt medical consultation is recommended.

If elevated transaminase levels are caused by physiological factors such as staying up late, alcohol consumption, or intense physical exercise, levels typically return to normal within about one week through lifestyle adjustments, including ensuring adequate sleep, complete abstinence from alcohol, and reducing high-intensity exercise. In such cases, no specific treatment is required—rest and dietary regulation are sufficient.

If the elevation is due to pathological conditions such as viral hepatitis, fatty liver disease, or drug-induced liver injury, treatment must target the underlying cause. For example, antiviral therapy is needed for viral hepatitis; dietary modification and increased physical activity are essential for fatty liver; and in cases of drug-induced liver injury, suspected medications should be discontinued and hepatoprotective drugs administered. Recovery in these cases usually takes longer, generally 2 to 4 weeks.

During treatment, liver function should be monitored regularly to track changes in transaminase levels. If enzyme levels remain elevated or are accompanied by symptoms such as fatigue or jaundice, immediate medical evaluation is necessary to rule out serious conditions like cirrhosis.