What does the negative conversion of surface antigen indicate?

　　HBsAg generally refers to hepatitis B surface antigen. The disappearance of hepatitis B surface antigen indicates effective suppression of hepatitis B virus replication and a significant reduction in viral load. It is an important sign of improvement in hepatitis B, suggesting that the infection status has improved. If this is accompanied by seroconversion to hepatitis B surface antibody positivity, the protective effect becomes more stable. However, if symptoms persist or laboratory indicators remain abnormal after antigen clearance, timely medical evaluation and retesting are recommended.

　　Hepatitis B surface antigen is a protein component of the outer shell of the hepatitis B virus. Its presence typically indicates active hepatitis B virus infection in the body. Antigen clearance means reduced viral replication activity, decreased viral attack on the liver, and lower risk of hepatocyte damage, reflecting clinical improvement due to treatment or immune control.

　　It should be noted that antigen clearance may be temporary, and cannot alone confirm complete recovery. A comprehensive assessment should include other hepatitis B serological markers (five-panel test), quantitative HBV DNA testing, and liver function tests to rule out occult viral replication and prevent misjudgment of disease status.

　　In daily life, maintain regular作息 (sleep-wake cycles) and avoid staying up late, quit smoking and drinking to reduce liver burden, follow a light and balanced diet rich in high-quality proteins and vitamins, avoid indiscriminate use of medications, undergo regular checkups for hepatitis B markers and liver function, and maintain a healthy lifestyle to consolidate and sustain improvements in disease status.