What are the causes of elevated aspartate aminotransferase isoenzymes?

Generally, elevated levels of aspartate aminotransferase isoenzyme may be caused by intense exercise, staying up late, viral hepatitis, myocardial infarction, biliary obstruction, and other reasons. If discomfort symptoms occur, it is recommended to seek timely medical treatment at a正规 hospital. The specific analysis is as follows:

1. Intense Exercise

Prolonged high-intensity physical activity increases metabolic activity in muscle cells, leading to minor cell damage and the release of enzymes into the bloodstream, causing elevated test results. Immediately stop strenuous activities, ensure adequate rest, and appropriately supplement with protein and vitamins. Re-examination after one week usually shows recovery.

2. Staying Up Late and Fatigue

Chronic sleep deprivation or excessive fatigue disrupts the liver's metabolic rhythm, resulting in mild liver cell damage and enzyme release into the blood. Adjust daily routines to become regular, ensure 7–8 hours of sleep per day, avoid staying up late, and maintain a light, easily digestible diet.

3. Viral Hepatitis

Hepatitis B or C viruses invade liver cells, damaging their structure and releasing enzymes into the blood, often accompanied by fatigue and reduced appetite. Medications such as entecavir tablets, tenofovir alafenamide fumarate tablets, or lamivudine tablets may be used under medical guidance. Maintain a light diet and avoid alcohol consumption.

4. Myocardial Infarction

Coronary artery blockage leads to ischemia and necrosis of heart muscle tissue; ruptured cells release large amounts of enzymes into the blood, often accompanied by chest pain and tightness. Immediate bed rest and prompt medical attention are required. Medications such as enteric-coated aspirin tablets, clopidogrel hydrogen sulfate tablets, or ticagrelor tablets may be prescribed. In severe cases, coronary stent implantation may be necessary.

5. Biliary Obstruction

Bile duct obstruction due to gallstones or bile duct narrowing impedes bile excretion, causing bile accumulation and liver cell injury, which elevates enzyme levels. Symptoms include jaundice and abdominal pain. Treatment under medical supervision may include ursodeoxycholic acid capsules, anti-inflammatory and cholagogue tablets, or cefuroxime axetil tablets. Severe cases may require bile duct stone removal via endoscopic procedures.

In daily life, maintain regular作息, avoid overexertion; engage in moderate exercise and avoid intense physical activity; follow a light diet and abstain from smoking and alcohol; undergo regular health check-ups to detect issues early; seek immediate medical care if symptoms such as chest pain or jaundice occur.