What medication is most effective for treating pasteurellosis?

Generally, there is no absolute "most effective" drug for treating Pasteurella infections; the choice of antibiotic should be based on the type and severity of infection as well as antimicrobial susceptibility testing. Seek prompt medical attention if any abnormalities occur. Detailed analysis is as follows:

Pasteurella is typically sensitive to penicillins, cephalosporins, fluoroquinolones, tetracyclines, and aminoglycosides. Mild cases can be treated with oral doxycycline or amoxicillin-clavulanate potassium, which provide coverage against common resistant strains. Severe or systemic infections require intravenous administration of ceftriaxone sodium or levofloxacin, or combination therapy with penicillin and gentamicin to enhance efficacy. If the infection spreads to sites such as the meninges or endocardium, agents with good tissue penetration—such as doxycycline combined with streptomycin—should be used, with treatment duration extended to 6–8 weeks.

Dosing adjustments are needed for special populations: tetracyclines are contraindicated in children; rifampin combined with trimethoprim-sulfamethoxazole is an alternative option. Pregnant women should avoid sulfonamides and may use rifampin combined with trimethoprim-methoxazole. For patients allergic to penicillin, fluoroquinolones or clindamycin are recommended alternatives.

Strict adherence to the prescribed treatment regimen is essential throughout the course of therapy to prevent the development of resistance due to premature discontinuation. Discontinue the medication immediately and return for reevaluation if allergic reactions such as rash or difficulty breathing occur, or if symptoms continue to worsen.